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Medicine Cialis: main features and mechanism of action

Description, Medical Information

Main action of Cialis

The active ingredient of this medicine is Tadalafil. The pharmacological action is based on the inhibition of cGMP. Nitric oxide is released during the sexual stimulation that leads to the inhibition of PDE5 and the increase of the concentration of cGMP in corpus cavernosum of the penis. Due to this the main pharmacological effect is occurred, i.e. the stable erection due to relaxation of smooth muscle of the penis and the improvement of blood supply. Pay attention that the indicated effect cannot be reached without a man’s sexual stimulation.

The active ingredient of Cialis does not inhibit other types of phosphodiesterase so does not influence the functions of organism. It does not impact cardiovascular system, the work of liver and cross-striated muscles. Also the research has shown that this medicine does not influence the quality of sperm, structure and mobility of spermatozoa. In addition Tadalafil does not change the level of sexual and other types of hormones. The effect comes after 20 minutes after administration, and the effect lasts more than 30 hours.

Cialis enters the bloodstream through the mucous membranes of the stomach. Its concentration in the blood reaches maximum within 2 hours after oral administration. Food or liquid intake does not influence this indicator. Cialis is actively excreted via the kidneys and intestines in the form of related substances.

Main indications for drug use:

Male erectile dysfunction.

How to use the medicine?

This drug is taken orally and is produce in tablet form. The tablet should be swallowed whole, without chewing and without dissolution. The attending physician prescribes the course and dosage of the drug. It is desirable to schedule the sexual intercourse and take 1 tablet 20 minutes before it. Daily and the maximum dose is 1 tablet.

Possible side effects

The patients’ reaction to Cialis is good, but in some cases the side effects were registered:

  • headaches of varying intensity
  • abnormality of bowel movement
  • periodical pain in the lumbar
  • redness of the face skin
  • runny nose
  • muscle pain or weakness
  • pain in the eyeballs
  • tearing
  • redness of the mucous membranes of the eyes
  • allergic reactions

In some cases, the patients had prolonged erection (over 4 hours). Such conditions require medical care, because they lead to malnutrition of the cavernous bodies of the penis and death of its cells.

Buy Cialis Online:

Some network pharmacies will sell Cialis online after an online consultation. Some pharmacies sell Cialis without a prescription, which they buy from an unlicensed seller, and it can be fake and ineffective at best and harmful at worst. You should go to the pharmacist and ask him to give you the medicine, and the pharmacist should ask a series of questions to make sure it is not harmful to you and to answer your questions, if any. It is very easy to buy Cialis online. Generic Cialis is often sold over the Internet without a prescription, this product can be bought with caution. The price of the original Cialis starts from 10 euros per pill, the generic Cialis can be bought 10 times cheaper.

Main list of contraindications

Cialis is contraindicated to woman and children under 18 years old. It is not prescribed to patients with hypersensitivity to the active ingredient of Cialis (Tadalafil). It is prohibited to patients, who administrate the nitrate containing medicines for cardiac insufficiency treatment.

A person, who suffer heart disease and the doctor forbids sexual contact, should refrain from taking the drug. Also the patients, who have suffered a heart attack, should also avoid Cialis use. The direct contraindication for Cialis use is heart failure II stage, angina, complex forms of arrhythmias, resistant hypertension, and states associated with a drop in blood pressure.

The physician should prescribe Cialis with caution if there is leukemia and anemia in the patient's history. It is prohibited to administrate this medicine if the patient has any form of curvature of penis and fibrous processes in the corpora cavernosa. Cialis can be prescribed for patients with chronic renal insufficiency after additional research. Also it is prohibited to coadministrate Cialis and anti-arrhythmic drugs on the basis of α and β - blockers.

Coadministaraion of Cialis and other medicines

Cialis cannot be combined with nitrates containing medicines. The concentration of Tadalafil in the blood may increase at coadministration of inhibitors of CYP3 A4 and Tadalafil. The special caution should be given at combination of hormones and erythromycin group of antibiotics. It was recorded a decrease in the level of Cialis in blood at simultaneous administration with rifampicine group of antibiotics. The level of Cialis absorption is greatly reduced at the treatment of peptic ulcer of the stomach by the drugs reducing acidity. It is undesirable to combine the use of this drug and the medicines lowering blood pressure.

Cialis 10 mg

Cialis 10 mg is a modern drug with improved composition in comparison to analogues and drugs of the previous generation. The composition of the drug has a safe effect on the body and a minimum of side effects. Unlike other drugs of the same group, alcohol can be used along with using Cialis 10 mg. The main active ingredient of the drug, Tadalafil, has a long duration in the body - up to 48 hours. To date, no drug on the pharmacological market does not have such a long effect period.

Cialis 20 mg

For the best effect, the drug Cialis 20 mg must be taken half an hour before the intended act. The first dose of the drug should be taken in a reduced dosage of 10 mg. This is necessary in order to assess the effect of the drug on the body and understand the results produced. It might turn out that a reduced dosage is sufficient. If the effect did not satisfy, then you can take a dose of 20 mg. This dosage is maximum intake for one day.

Cialis 40 mg

Best of all, the medicine will work if you resort to it 30-40 minutes before intimacy. The usage dose should be 20 milligrams. But there are such forms of the disease where effectiveness cannot be achieved, then the dose should be increased to 40 milligrams. At the same time, remember that in one day you can use only one pill. Be careful with the dosage! An erection lasting over four hours in a row, however, should raise an alarm.

Cialis 60 mg

Cialis 60 mg is an effective drug for enhancing male potency, which even in difficult cases of sexual impotence is able to provide a stable erection during 36 hours after taking it.

The drug is taken 30 - 40 minutes before the intended sexual intercourse. The recommended dosage is 30 mg. In the absence of the desired effect, it is allowed to increase this dose two times, i.e. up to 60 mg. A further increase in drug concentration can lead to negative side effects associated with drug overdosage.

Cialis Professional

Generic Cialis Professional 20 mg is a unique pharmacological remedy that is used to restore erectile function in men. Its new, improved composition guarantees an appearance of a long and stable erection, which makes it possible to take sexual relations to a new, higher quality level. Taking the drug contributes to the maximum filling of the penis with blood, as a result of which it becomes more solid and increases in volume.

The medication is taken orally, washed down with a large amount of water, 30-40 minutes before the start of sexual intercourse. A sufficient dosage is 20 mg. The drug provides a stable erection for one and a half days. This means that only one tablet of Cialis Professional 20 mg allows you to forget about sexual problems and get maximum pleasure from intimacy for two days.

Cialis Soft

Cialis Soft is prescribed for a complex treatment of problems associated with erection and sexual dysfunction that occur in men of different ages. Positive results are achieved regardless of the stage and degree of symptoms that appear as well as in cases when the disorders are associated with psychosomatics. A distinctive feature of Cialis Soft is that there are no contraindications for use if you have heart, blood vessels, kidneys or liver illnesses. The drug does not work wonders but helps to activate the natural erection arising from sexual desire.

Cialis Super Active

Cialis Super Active - a drug consisting of two components, is available in pill form. Tadalafil is a component of the pharmacological group that gives a positive result in the fight against all the problems of male sexual dysfunction. The effect of this component depends entirely on the strength of sexual desire, and then the parasympathetic nervous system takes over. It is the nervous system that creates the impulses that release the mediators of selective action, which in turn help to relax the musculature of the male organ’s cavernous bodies, increasing blood supply. As a result, there is a hard, quality erection.

Overdosage

It is possible the development of adverse reactions and negative effects at increasing dose over the therapeutic one. The direct antagonist to Tadalafil does not exist. The symptomatic treatment should be prescribed at the side effects or an overdose. There will be no result for blood purification by means of dialysis, because the active substance is well associated with the blood proteins.

For example: at a sharp decrease in blood pressure, the patient should be laid on the bed and raise his legs up. The patient should be released from pressure clothes and to provide fresh air. At first signs of an allergic reaction the patient should immediately cease the administration of the drug, try to induce vomiting and cleanse the stomach with activated coal. The patient should pay special attention to blood pressure and respiratory function. In case of respiratory arrest, it is necessary to apply cardiopulmonary resuscitation, making mouth-to-mouth ventilation. Before the doctor’s arrival it is necessary to take history and to find out what drugs in addition to Tadalafil the patient took. This information will expedite the provision of medical assistance and its quality.

It is necessary to call an ambulance and wait for arrival of doctors before starting the abovementioned activities.

Storage

The drug should be kept at a dry place, at the temperature from 15C to 30C.